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Background: Calcium and vitamin D malabsorption in celiac disease (CD) predispose to high bone turnover and skeletal demineralization. Osteoprotegerin (OPG), a member of the tumor necrosis factor receptor family, and ligand of receptor activator of NFkB (RANKL) inhibits osteoclast formation and activity.The aim of this study was to evaluate the relationship between bone mineral density (BMD), bone-turnover markers and osteprotegerin in adult patients wit...

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ea0014p417 | (1) | ECE2007

Is there any relationship between the BsmI polymorphism in the vitamin D receptor gene and the occurrence of glucocorticoid-induced osteoporosis in asthmatic patients with long-term glucocorticoid treatment?

Tworowska Urszula , Bidzinska-Speichert Bozena , Obojski Andrzej , Demissie Marek , Slezak Ryszard , Lenarcik Agnieszka , Milewicz Andrzej

Introduction: Results of many studies indicate that BsmI polymorphism in VDR gene may influence bone tissue metabolism and may be useful in identifying patients at greater risk of glucocorticoid-induced osteoporosis.Aim of the study: To determine frequency of polymorphic variants of VDR gene (BsmI) and its relationship to phenotypic features characterizing bone status (BMD and metabolic bone turnover).Material and methods: Followin...

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Endocrine Abstracts

Osteoprotegerin and bone mineral density in adult patients with celiac disease

Is there any relationship between the BsmI polymorphism in the vitamin D receptor gene and the occurrence of glucocorticoid-induced osteoporosis in asthmatic patients with long-term glucocorticoid treatment?

BiosciAbstracts